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Triethylbenzylammonium Chloride as a Useful and Efficient Catalyst for the Alkylation of Indole/substituted Indoles in Water: A Comparative Study between Conventional and Microwave Irradiation
Author(s) -
Tumtina Shokip,
Kathing Chingrishon,
Phucho Ivulho Tovishe,
grum Ridaphun,
Myrboh Bekington,
gkhlaw Rishanlang
Publication year - 2015
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201400221
Subject(s) - indole test , chemistry , alkylation , catalysis , microwave irradiation , chloride , organic chemistry , combinatorial chemistry
A green and facile method for the alkylation of indole/substituted indole in water using a phase Transfer catalyst (Triethylbenzylammonium Chloride, TEBA) to synthesise bis‐indolyl methanes (BIMs) and Michael addition of indole to α,β‐unsaturated carbonyl compounds is reported. The substitution of indoles occurred exclusively at the 3‐position and products of N‐alkylation has not been observed. However, for 3‐substituted indoles, reactions were found to occur at the 2‐position. A comparative study between conventional heating and microwave irradiation has also been reported.