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Syntheses, Structures and Anticancer Activity of NNO‐Tridentate Schiff Base Copper(II) Complexes
Author(s) -
Lin RongKai,
Hsu ChoHan,
Chiu ChinI,
Lai YingJu,
Lai a FengJie,
Chien ChingMing,
Lin ChuChieh
Publication year - 2014
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201400174
Subject(s) - chemistry , schiff base , copper , hela , ligand (biochemistry) , square pyramidal molecular geometry , stereochemistry , crystal structure , cytotoxicity , bipyridine , crystallography , medicinal chemistry , organic chemistry , receptor , in vitro , biochemistry
A series of heteroleptic copper(II) complexes [Cu( R QYMP )(Py]] ( 1a ‐ 4d ) supported on NNO‐tridentate Schiff base ( R QYMP ‐H) and bipyridine (Py=bpy, a ; phen, b ; dpq, c ; dppz, d ) co‐ligands have been synthesized and characterized. X‐ray crystal structural studies of complexes 1b , 2c , 3d and 4a displays that these complexes are mononuclear with a distorted square pyramidal geometry around the copper center. Cytotoxicity results indicate that all of these complexes have much higher activity against HeLa, SCC15, BCC and Ca9‐22 cancer cell lines as compared to cisplatin. Further, copper complex bearing suitable bulky group Schiff base ligands with dppz co‐ligand could be considered in designing efficient metalbased anticancer agents.