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A Convenient Preparation of Bis(4‐methoxyphenyl)methanethiol and Its Application in the Synthesis of Biotin Thioacid
Author(s) -
Chou TzyyChao,
Hsu YuLing,
Lo LeeChiang
Publication year - 2014
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201300664
Subject(s) - methanethiol , chemistry , thioester , biotin , reagent , yield (engineering) , thiol , organic chemistry , combinatorial chemistry , biochemistry , sulfur , materials science , metallurgy , enzyme
We have established a facile protocol for the preparation of bis(4‐methoxyphenyl)methanethiol ( 4 ). Thiol 4 was used to prepare biotin thioester 7 which was later subjected to acidolysis to afford biotin thioacid ( 1b ) in high yield. Compound 1b represents a new biotinylating reagent worth exploring and its spectral data was reported for the first time.