A Convenient Preparation of Bis(4‐methoxyphenyl)methanethiol and Its Application in the Synthesis of Biotin Thioacid | Zendy

Chou TzyyChao | Zendy; Hsu YuLing | Zendy; Lo LeeChiang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A Convenient Preparation of Bis(4‐methoxyphenyl)methanethiol and Its Application in the Synthesis of Biotin Thioacid

Author(s) -

Chou TzyyChao,

Hsu YuLing,

Lo LeeChiang

Publication year - 2014

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.201300664

Subject(s) - methanethiol , chemistry , thioester , biotin , reagent , yield (engineering) , thiol , organic chemistry , combinatorial chemistry , biochemistry , sulfur , materials science , metallurgy , enzyme

We have established a facile protocol for the preparation of bis(4‐methoxyphenyl)methanethiol ( 4 ). Thiol 4 was used to prepare biotin thioester 7 which was later subjected to acidolysis to afford biotin thioacid ( 1b ) in high yield. Compound 1b represents a new biotinylating reagent worth exploring and its spectral data was reported for the first time.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research