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One‐pot Synthesis of 2,5‐Disubstituted‐1,3,4‐oxadiazoles Based on the Reaction of N , N ‐Dimethyl Amides with Acid Hydrazides
Author(s) -
Li Qiang,
Tao Yi,
Xu Dongfang,
Zhang Haobing,
Duan Liping
Publication year - 2014
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201300598
Subject(s) - chemistry , hydrazide , yield (engineering) , aryl , organic chemistry , one pot synthesis , reaction conditions , combinatorial chemistry , catalysis , alkyl , materials science , metallurgy
Convenient and efficient one pot method for the synthesis of 2,5‐disubstituted‐1,3,4‐oxadiazoles based on the reaction of N , N ‐dimethyl amides with acid hydrazides has been developed. The methodology is applied to a wide range of difference aryl hydrazide and difference N , N ‐dimethyl amides to 2,5‐disubstituted‐1,3,4‐oxadiazoles yield the in good to excellent yields. It will be possible wide useful application in synthesis.