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Synthesis, Characterization and Evaluation of Antimicrobial and Antituberculosis Activities of New N ‐(Substituted‐thioureido)aminobicyclo Dicarboximide and 3,4‐Disubstituted 1,2,4‐Triazolino‐5‐thione
Author(s) -
PachutaStec Anna,
Kosikowska Urszula,
Mazur Liliana,
SwatkoOssor Marta,
Pitucha Monika,
Malm Anna,
Ginalskad Grażyna
Publication year - 2014
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201300362
Subject(s) - chemistry , antimicrobial , elemental analysis , bicyclic molecule , stereochemistry , carbon 13 nmr , proton nmr , organic chemistry , combinatorial chemistry
The novel N ‐(substituted‐thioureido)aminobicyclo dicarboximide and 3,4‐disubstituted 1,2,4‐triazolino‐5‐thione were synthesized and their antimicrobial and antituberculosis activities were examined. Selected dicarboxylic acid anhydrides were used to obtain derivatives of thiosemicarbazide and dicarboximide. Dicarboximides were also cyclized in the presence of an alkaline solution giving 1,2,4‐triazolino‐5‐thione. The chemical structure of all compounds was confirmed by IR, 1 H NMR, 13 C NMR, the X‐ray crystallography ( 6 , 11 ) and elemental analysis. Antimicrobial and antituberculosis activities of the derivatives were measured.