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An Efficient One‐pot Access to Substituted Dihydropyrrol‐2‐one Derivatives Using Sucrose as Natural, Biodegradable and Inexpensive Catalyst
Author(s) -
Hazeri Nourallah,
Sajadikhah Seyed Sajad,
Maghsoodlou Malek Taher,
MohamadianSouri Sajad,
Norouzi Mahmoud,
Moein Maryam
Publication year - 2014
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201300311
Subject(s) - chemistry , catalysis , formaldehyde , organic chemistry , condensation , sucrose , combinatorial chemistry , condensation reaction , physics , thermodynamics
Abstract An efficient and simple procedure for the synthesis of highly substituted dihydropyrrol‐2‐ones has been developed via one‐pot four‐component condensation of amines, dialkyl acetylenedicarboxyaltes and formaldehyde in the presence of sucrose as an organocatalyst. The salient advantages of this method are using a natural, biodegradable and commercial available catalyst, good yields, short reaction times, simple work‐up and lack of need for column chromatography.