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Chemoselective Synthesis of β‐Amino Ester or β‐Lactam via Sonochemical Reformatsky Reaction
Author(s) -
Lee Adam ShihYuan,
Chang YuTing,
Su FengYi
Publication year - 2014
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201300308
Subject(s) - chemistry , aldimine , reformatsky reaction , ethyl bromoacetate , substrate (aquarium) , reaction conditions , lactam , tosyl , organic chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , catalysis , oceanography , geology
A series of β‐amino esters were synthesized by the reaction of N ‐tosyl aldimine or N ‐hydroxy aldimine with bromoacetate by sonochemical Reformatsky reaction. The β‐ N ‐hydroxyamino ester was obtained and the formed sensitive hydroxylamino functionality was resistant under the reaction condition. The β‐lactam also was synthesized by the reaction of N ‐ p ‐methoxy aldimine as reacting substrate under this sonochemical Reformatsky reaction condition.