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Evaluation of Antimicrobial Activity of Some Newly Synthesized 4‐Thiazolidinones
Author(s) -
Abdulkader Saleh Nabil,
Elabd Saltani Hussein,
Abbas AlIssa Fadhil,
Gomaa Melad AlSadek
Publication year - 2013
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201300047
Subject(s) - chemistry , antimicrobial , candida albicans , antifungal , antibacterial activity , antibiotics , corpus albicans , bacteria , combinatorial chemistry , stereochemistry , microbiology and biotechnology , organic chemistry , biochemistry , genetics , biology
The antimicrobial activity of thirteen newly synthesized 4‐thiazolidinones (TZONs) and four dithiolane derivatives was assessed against susceptible and resistant bacteria, including MRSA, as well as Candida albicans. The structure‐activity relationships revealed that 4‐Thiazolidinone derivatives harboring p‐chlorophenyl and dicarboxyethyl at the 2‐ethenyl and 5‐arylidine positions of the thiazolidinone ring display considerable antibacterial properties. No antifungal activity was recorded by all tested compounds against Candida albicans. The possible potentiative (synergistic) effect of the most active compounds to a few commercial antibiotics was also investigated.