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Synthesis of Tetradentate Schiff Base Derivatives of Transition Bimetallic Complexes as Antimicrobial Agents
Author(s) -
Yousaf Muhammad,
Pervaiz Muhammad,
Sagir Muhammad,
Zaman Ashharuz,
Mushtaq Muhammad,
Naz Muhammad Yasin
Publication year - 2013
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201200628
Subject(s) - chemistry , schiff base , ligand (biochemistry) , bimetallic strip , aspergillus niger , salicylaldehyde , condensation reaction , antimicrobial , aspergillus flavus , hydrazine (antidepressant) , polymer chemistry , proton nmr , stereochemistry , organic chemistry , medicinal chemistry , catalysis , biochemistry , receptor , food science
A series of Co(II), Cu(II), Mn(II) and Zn(II) bimetallic complexes have been synthesized with the schiff base ligand 2‐(bis‐2‐hydroxyl phenylidene) diimine (L) derived from the condensation of hydrazine and salicylaldehyde. The synthesized ligand and bimetallic complexes were characterized by different spectroscopic techniques. The characterization of ligand was carried out by FT‐IR, H 1 NMR, C 13 NMR and MS while the bimetallic complexes were characterized by FT‐IR and X‐ray crystallographic techniques. The complexes and ligand were employed in vitro for antifungal and antibacterial activities using disc diffusion method. Different fungal strains such as Alternaria Alternate, Aspergillus Flavus and Aspergillus Niger were used to check antifungal activities of bimetallic complexes and ligand. Similarly, the bacterial strains used were Staphylococcus Aureus, Bacillus Subbtilis and Escheria Coli. The biological studies showed that the ligand exhibited lower value of antifungal and antibacterial activities than bimetallic complexes.