Controlled Friedel‐Crafts Acylation of 3,6‐Disubstituted‐ 9H ‐carbazole | Zendy

Lee TingYu | Zendy; Yeh MingChe | Zendy; Chang LingChueh | Zendy; Ong ChiWi | Zendy; Lin CheYu | Zendy; Huang JuiHsien | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Controlled Friedel‐Crafts Acylation of 3,6‐Disubstituted‐ 9H ‐carbazole

Author(s) -

Lee TingYu,

Yeh MingChe,

Chang LingChueh,

Ong ChiWi,

Lin CheYu,

Huang JuiHsien

Publication year - 2013

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.201200575

Subject(s) - chemistry , friedel–crafts reaction , carbazole , acylation , alkylation , steric effects , medicinal chemistry , diacetyl , organic chemistry , catalysis

1,8‐Dicarbonylcarbazoles are important starting materials for various applications, especially for pincer‐type ligands. The convenient synthesis of a series of 1,8‐diacyl‐3,6‐di‐ tert ‐butyl‐9 H ‐carbazoles ( 2 ) by the direct Friedel‐Crafts acylation of 3,6‐di‐ tert ‐butyl‐9 H ‐carbazole ( 1 ) is described. During the reaction, the dealkylation also occurred, and 1,8‐diacetyl‐3‐ tert ‐butyl‐9 H ‐carbazole ( 4 ) was isolated as well as characterized by an X‐ray diffraction analysis. In addition, the steric bulkiness of the acyl chlorides strongly affects the yields of 1,8‐diacylation of 1 .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research