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An Expedient Stereoselective Synthesis of Spirocyclopropyl Oxindoles from Indolin‐2‐One/ N ‐Protected Indolin‐2‐Ones and Bromonitroalkenes
Author(s) -
Roy Suparna,
Chen Kwunmin
Publication year - 2013
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201200557
Subject(s) - chemistry , diastereomer , stereoselectivity , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
A direct and much simpler way was developed for the diastereoselective synthesis of spiro cyclopropan‐1,3′‐oxindoles from indolin‐2‐one/ N ‐protected indolin‐2‐ones and bromonitroalkene. The fused restrained cyclopropanes were obtained with high diastereomeric ratios (upto >99:1) and in reasonable to high isolated chemical yields (upto 94%).