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Biological Evaluation of Some Antimicrobial Nano‐Materials
Author(s) -
Mokhtari Bahram,
Pourabdollah Kobra
Publication year - 2013
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201200531
Subject(s) - benzothiazole , chemistry , antimicrobial , piperidine , mtt assay , acetamide , bacteria , pathogenic bacteria , stereochemistry , organic chemistry , combinatorial chemistry , nuclear chemistry , biochemistry , in vitro , biology , genetics
N ‐(benzothiazol‐2‐yl)‐2‐(piperidin‐1‐yl)acetamide derivatives ( 1‐24 ) were obtained by the reaction of 2‐chloro‐ N ‐(benzothiazole‐2‐yl)acetamides with piperidine derivatives. The structures of the compounds were elucidated by 1 H‐NMR and mass spectral data and elemental analysis. The compounds were screened for their antimicrobial activities against pathogenic bacteria and Candida species. The compounds were also investigated for their cytotoxic properties using MTT assay. The microbiological results revealed that the compounds were more effective against fungi than bacteria. Among Candida species, C. utilis was the most susceptible fungus to compounds 7 and 11 . It is apparent that 2,6‐dimethylpiperidine group and chloro and methyl substituents on benzothiazole ring have an important impact on anticandidal activity. MTT assay indicated that the effective doses of these derivatives were lower than their cytotoxic doses.