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Combinatorial Library Synthesis of N‐arylquinoline Derivatives in Aqueous Medium
Author(s) -
Moshtaghi Zonouz Adeleh,
Raeisolsadati Oskouei Mina
Publication year - 2013
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201200359
Subject(s) - chemistry , dimedone , malononitrile , aniline , quinoline , ethanol , imidazole , organic chemistry , aqueous medium , catalysis , aryl , combinatorial chemistry , aqueous solution , alkyl
N‐aryl quinoline derivatives have been prepared by sequential one‐pot reaction of dimedone, aniline, malononitrile and arylaldehydes. The reactions were performed in two different conditions, refluxing in ethanol without catalyst and heating in ethanol/water (1:1) in the presence of imidazole as an organocatalyst. Use of organocatalyst causes shorter reaction times and higher yields.