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An Efficient, Mild and Scalable Synthesis of Bioactive Compounds Containing the Angelicin Scaffold
Author(s) -
HuiYi Shiao,
ChingChuan Kuo,
JimTong Horng,
ShinRu Shih,
SuiYuan Chang,
ChunChen Liao,
John T.A. Hsu,
Prashanth Kumar Amancha,
YuSheng Chao,
HsingPang Hsieh
Publication year - 2012
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201200233
Subject(s) - chemistry , scaffold , combinatorial chemistry , scalability , key (lock) , computer science , programming language , database , computer security
Abstract An efficient, mild and scalable synthesis of angelicin scaffold based compounds was developed. Particularly, the new synthetic route described here circumvents the need for the previously reported key Fries rearrangement step, which uses impractically harsh conditions. The new methodology is applied to the synthesis of several, previously reported analogs of angelicin which have potent anti‐influenza and anti‐cancer activities.