Solvent‐free Synthesis of Novel and Known Octahydroquinazolinones/thiones by the Use of ZrOCl 2 .8H 2 O as a Highly Efficient and Reusable Catalyst | Zendy

Karami Sajad | Zendy; Karami Bahador | Zendy; Khodabakhshi Saeed | Zendy

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Solvent‐free Synthesis of Novel and Known Octahydroquinazolinones/thiones by the Use of ZrOCl 2 .8H 2 O as a Highly Efficient and Reusable Catalyst

Author(s) -

Karami Sajad,

Karami Bahador,

Khodabakhshi Saeed

Publication year - 2013

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.201200145

Subject(s) - dimedone , chemistry , thiourea , catalysis , urea , zirconium , lewis acids and bases , barbituric acid , solvent , organic chemistry

A solvent‐free reaction between urea/thiourea, dimedone and aromatic aldehydes in the presence of catalytic amounts of zirconium (IV) oxychloride octahydrate (ZrOCl 2 .8H 2 O) as a powerfull Lewis acid leads to octahydroquinazolinone/thione derivatives in good yields. This method has advantages such as avoidance of the organic solvents, production of pure products without any by‐product, short reaction times and simple operation.

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