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Sterols from the Stems of Momordica charantia
Author(s) -
Liao YunWen,
Chen ChiyRong,
Hsu JueLiang,
Cheng HsuehLing,
Shih WenLing,
Kuo YuehHsiung,
Huang TzouChi,
Chang ChiI
Publication year - 2011
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201190141
Subject(s) - chemistry , momordica , stereochemistry , sterol , ergosterol , diene , organic chemistry , biochemistry , traditional medicine , cholesterol , medicine , natural rubber
A new sterol, 5α,6α‐epoxy‐3β‐hydroxy‐(22 E ,24 R )‐ergosta‐8,22‐dien‐7‐one ( 1 ), together with eight known sterols, 5α,6α‐epoxy‐(22 E ,24 R )‐ergosta‐8,22‐diene‐3β,7α‐diol ( 2 ), 5α,6α‐epoxy‐(22 E ,24 R )‐ergosta‐8,22‐diene‐3β,7β‐diol ( 3 ), 5α,6α‐epoxy‐(22 E ,24 R )‐ergosta‐8(14),22‐diene‐3β,7α‐diol ( 4 ), 3β‐hydroxy‐(22 E ,24 R )‐ergosta‐5,8,22‐trien‐7‐one ( 5 ), ergosterol peroxide ( 6 ), clerosterol ( 7 ), decortinol ( 8 ), and decortinone ( 9 ), were isolated from the stems of Momordica charantia . Their structures were elucidated by mean of extensive spectroscopic methods, including 1 H, 13 C, 2D‐NMR and HR‐EI‐MS, as well as comparison with the literature data. Compounds 1 , 4 , 5 , 8 , and 91 were not cytotoxic against the SK‐Hep 1 cell line.