Sterols from the Stems of  Momordica charantia | Zendy

Liao YunWen | Zendy; Chen ChiyRong | Zendy; Hsu JueLiang | Zendy; Cheng HsuehLing | Zendy; Shih WenLing | Zendy; Kuo YuehHsiung | Zendy; Huang TzouChi | Zendy; Chang ChiI | Zendy

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Sterols from the Stems of Momordica charantia

Author(s) -

Liao YunWen,

Chen ChiyRong,

Hsu JueLiang,

Cheng HsuehLing,

Shih WenLing,

Kuo YuehHsiung,

Huang TzouChi,

Chang ChiI

Publication year - 2011

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.201190141

Subject(s) - chemistry , momordica , stereochemistry , sterol , ergosterol , diene , organic chemistry , biochemistry , traditional medicine , cholesterol , medicine , natural rubber

A new sterol, 5α,6α‐epoxy‐3β‐hydroxy‐(22 E ,24 R )‐ergosta‐8,22‐dien‐7‐one ( 1 ), together with eight known sterols, 5α,6α‐epoxy‐(22 E ,24 R )‐ergosta‐8,22‐diene‐3β,7α‐diol ( 2 ), 5α,6α‐epoxy‐(22 E ,24 R )‐ergosta‐8,22‐diene‐3β,7β‐diol ( 3 ), 5α,6α‐epoxy‐(22 E ,24 R )‐ergosta‐8(14),22‐diene‐3β,7α‐diol ( 4 ), 3β‐hydroxy‐(22 E ,24 R )‐ergosta‐5,8,22‐trien‐7‐one ( 5 ), ergosterol peroxide ( 6 ), clerosterol ( 7 ), decortinol ( 8 ), and decortinone ( 9 ), were isolated from the stems of Momordica charantia . Their structures were elucidated by mean of extensive spectroscopic methods, including 1 H, 13 C, 2D‐NMR and HR‐EI‐MS, as well as comparison with the literature data. Compounds 1 , 4 , 5 , 8 , and 91 were not cytotoxic against the SK‐Hep 1 cell line.

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