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A Novel and Efficient Synthesis of Dronedarone Hydrochloride, an Antiarrhythmic Drug Substance
Author(s) -
Mohanarangam Saravanan,
Satyanarayana Bollikonda,
Elati Chandrashekar R.,
Vijayabhaskar Bolugoddu,
Pratap Reddy Padi
Publication year - 2011
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201190133
Subject(s) - chemistry , dronedarone , hydrochloride , combinatorial chemistry , drug , pharmacology , organic chemistry , amiodarone , atrial fibrillation , medicine
A novel and efficient synthesis of dronedarone hydrochloride starting from 2‐n‐butyl‐5‐nitrobenzofuran by employing mild and selective reaction conditions is described. The synthetic approach is operationally simple and suitable for industrial application.