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Thiourea: An Efficient and Inexpensive Catalyst for the Knoevenagel Condensation of Pyrazole Derivates
Author(s) -
Li JianPing,
Qiu JiKuan,
Li HuiJuan,
Zhang GuiSheng
Publication year - 2011
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201190087
Subject(s) - knoevenagel condensation , chemistry , thiourea , pyrazole , aldehyde , catalysis , methylene , organic chemistry , condensation , physics , thermodynamics
Thiourea is an inexpensive, efficient and mild catalyst for the synthesis of Knoevenagel condensation of pyrozoles derivate. In the presence of 10 mol% of thiourea, pyrazole aldehyde react with active methylene compound under microwave‐assisted solvent‐free conditions at 300 W for 2‐5 min to give corresponding products in good yields.