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Synthesis and Biological Evaluation of New Fused Isoxazolo[4,5‐d] Pyridazine Derivatives
Author(s) -
Faidallah Hassan M.,
Khan Khalid A.,
Makki Mohammed S. I.
Publication year - 2011
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201190076
Subject(s) - chemistry , pyridazine , antifungal , ring (chemistry) , tricyclic , combinatorial chemistry , stereochemistry , antibacterial activity , organic chemistry , bacteria , dermatology , medicine , biology , genetics
Abstract Three new heterocyclic ring systems, isoxazolo[4,5‐d]‐1,2,4‐triazolopyridazines 12‐15 , tetrazolo‐[4,3‐b]pyridazine 18 and isoxazolo[4,5‐d]pyridazino[2,3‐c]2H‐triazines 16 , 17 along with isoxazolo[4,5‐d]pyridazines 2 , 5‐10 have been synthesized. Preliminary screening of these tricyclic heterocycles revealed that some of them possess significant antibacterial and antifungal activity.