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Microwave‐assisted Friedländer Synthesis of Polysubstituted Quinolines Based on Poly(ethylene glycol) Bound Acetoacetate
Author(s) -
Zhang XiaoLiang,
Hu QiaoSheng,
Sheng ShengRi,
Xiao Chen,
Cai MingZhong
Publication year - 2011
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201190052
Subject(s) - chemistry , ethylene glycol , peg ratio , polyethylene glycol , ethyl acetoacetate , condensation , cleavage (geology) , yield (engineering) , catalysis , microwave irradiation , polymer , copolymer , organic chemistry , polymer chemistry , metallurgy , physics , materials science , geotechnical engineering , finance , fracture (geology) , engineering , economics , thermodynamics
Polysubstituted quinolines were efficiently prepared on the soluble polyethylene glycol (PEG) by microwave irradiation Friedländer condensation of PEG bound acetoacetate with 2‐aminoarylketones promoted by catalytic amount of polyphosphoric acid, and subsequently cleavage from the PEG with MeONa in MeOH. The polymer‐supported synthesis provided the target compounds in excellent yield and purity with a facile work‐up procedure.