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A Facile Synthesis and Structural Verification of Etorphine and Dihydroetorphine from Codeine
Author(s) -
Huang XinRen,
Srimurugan Sankareswaran,
Lee GeneHsiang,
Chen Chinpiao
Publication year - 2011
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201190048
Subject(s) - chemistry , etorphine , codeine , morphine , yield (engineering) , pharmacology , opioid , biochemistry , receptor , medicine , (+) naloxone , materials science , metallurgy
In this study, an improved process for the synthesis of etorphine and dihydroetorphine from codeine with an overall yield of 2.7% and 1.5% respectively is described. The structure of 19‐propylthevinol 7 was verfied by X‐ray structure analysis. This result is promising for synthesizing various morphine‐based drugs.