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Synthesis and Crystal Structure Determination of [H2‐cryptand 222](Br 3 ) 2 : A Unique Tribromide Catalyst for the Catalytic Chemoselective N ‐Boc Protection of Amines
Author(s) -
Chehardoli Gholamabbas,
Zolfigol Mohammad Ali,
Khakyzadeh Vahid,
Golbedaghi Reza,
Hall Nikita A.,
Blackman Allan G.
Publication year - 2011
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201190018
Subject(s) - chemistry , tribromide , cryptand , catalysis , primary (astronomy) , crystal structure , cyclic amines , organic chemistry , medicinal chemistry , ion , physics , astronomy
The organic tribromide, [H 2 ‐cryptand 222](Br 3 ) 2 was synthesized and characterized by X‐ray crystallography, and was utilized as an active catalyst for the N ‐boc protection of amines. The method is general for the preparation of N ‐boc derivatives of aliphatic (acyclic and cyclic), aromatic, primary and secondary amines. We also applied our new reaction protocols for the N ‐boc protection of some new amines and spectral and physical data for the obtained products are reported.