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FeCl 3 Catalyzed Barbier Homocoupling Reaction for Synthesis of Symmetric Biaryls
Author(s) -
Lee Adam ShihYuan,
Chen PinLung,
Chang YuTing,
Tsai HengTser
Publication year - 2012
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201100679
Subject(s) - chemistry , reagent , catalysis , magnesium bromide , aryl , bromide , magnesium , reaction conditions , grignard reagent , organic chemistry , combinatorial chemistry , alkyl
A series of biaryls and biheteroaryls were synthesized by the Barbier reaction of aryl bromide with magnesium powder and 1,2‐dibromoethane in the presence of FeCl 3 in THF under reflux reaction condition. The catalytic system differentiates itself from other homocoupling reactions catalyzed by iron salts in that it requires neither the preliminary preparation of Grignard reagent nor the addition of an oxidant.