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A Simple, Mild and Efficient One‐Pot Synthesis of 2‐Substituted Benzimidazoles in the Presence of H 2 O 2 /HCl under Microwave Irradiation
Author(s) -
Naeimi Hossein,
Alishahi Nasrin
Publication year - 2012
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201100591
Subject(s) - chemistry , microwave irradiation , benzimidazole , acetonitrile , microwave , irradiation , o phenylenediamine , combinatorial chemistry , simple (philosophy) , one pot synthesis , nuclear chemistry , organic chemistry , catalysis , physics , quantum mechanics , nuclear physics , philosophy , epistemology
A simple, fast and efficient method for the preparation of several 2‐substituted benzimidazole derivatives is reported. Compounds were synthesized through a rapid one‐pot synthesis via microwave irradiation, starting from aldehydes and o ‐phenylenediamine, in the presence of H 2 O 2 /HCl system in acetonitrile. The significant features of this method are short reaction times, high yields, easy and quick isolation of the products.