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In vitro Inhibition Effect of Transition Metal Ions on Succinate‐Fumarate System in ATP Cycle
Author(s) -
Farrukh Muhammad Akhyar,
Majeed Sana
Publication year - 2012
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201100518
Subject(s) - chemistry , ferricyanide , potassium ferricyanide , inorganic chemistry , metal ions in aqueous solution , metal , redox , kinetics , ion , aqueous solution , nuclear chemistry , reaction rate constant , organic chemistry , physics , quantum mechanics
Oxidation of sodium succinate in aqueous solution by potassium ferricyanide was investigated. The effects of different reaction parameters such as initial concentration of succinate, concentration of ferricyanide, and influence of metal ions (Zn +2 , Ni +2 , Cu +2 , Cd +2 ) on the oxidation of succinate were investigated at 25 ± 0.05 °C. Large rate enhancements were observed in the redox reaction between succinate and ferricyanide with increasing concentrations of both oxidant and reductant. The kinetics results indicated that the succinate oxidation was significantly inhibited in the presence of metal ions. Pseudo first order rate constants values were found decreased with increase in concentrations of metal ions which reflected that inhibition rate was directly influenced with the metal ions concentration.