Premium
Synthesis, Structural Characterization and Biological Activity of Cu(II) Compounds Incorporating Pyrazole‐derived Ligand: Effect on Cell Growth in Human Colorectal Carcinoma
Author(s) -
Li ChenYi,
Lien YuLing,
Datta Amitabha,
Chiu WanTing,
Hsu ChinLin,
Huang JuiHsien,
Horng Lance,
Lin ChiaHer,
Su ChiJung
Publication year - 2012
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201100396
Subject(s) - chemistry , ligand (biochemistry) , pyrazole , amine gas treating , stereochemistry , copper , chloride , cell growth , medicinal chemistry , biochemistry , receptor , organic chemistry
A series of Cu(II) compounds containing neutral multi‐dentate ligand [2,6‐diisopropylphenyl]‐bis[(1‐H‐pyrazol‐1‐yl)methyl]amine ( L 1 ) and pyrazole dimethoxethyl ligand [(1‐H‐pyrazol‐1‐yl)methyl]‐bis(2‐methoxyethyl)amine ( L 2 ) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1 CuCl 2 ( 1 ) and L 2 CuCl 2 ( 2 ), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X‐ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT‐29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT‐29 cells).