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Tetrabutylammonium Fluoride (TBAF) Catalysed Synthesis of 2‐Arylbenzimidazole in Water under Ultrasound Irradiation
Author(s) -
Joshi Ratnadeep S.,
Mandhane Priyanka G.,
Dabhade Sanjay K.,
Gill Charansingh H.
Publication year - 2010
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201000181
Subject(s) - chemistry , benzimidazole , yield (engineering) , catalysis , environmentally friendly , aldehyde , selectivity , tetrabutylammonium fluoride , green chemistry , organic chemistry , nuclear chemistry , combinatorial chemistry , reaction mechanism , metallurgy , ecology , materials science , biology
One‐pot multistep reactions involving a new environmentally friendly catalytic procedure have been developed for the synthesis of benzimidazole. The reaction of the substituted aldehyde with o ‐phenylenediamine in water under ultrasonic irradiation at ambient temperature for appropriate time using 5 mol% of TBAF furnish the desired product in good to excellent yield. The process is green, mild, inexpensive, excellent chemo selectivity, and excellent yields are the main advantages of this procedure.