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Me 3 SiOTf Promoted Aza‐Michael Addition Reaction of 1°‐Amides with α,β‐Unsaturated Ketones
Author(s) -
Lee Adam ShihYuan,
Lin MeiChun,
Lin ChihChen,
Chang YuTing
Publication year - 2010
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201000110
Subject(s) - chemistry , michael reaction , ketone , amide , lewis acids and bases , addition reaction , organic chemistry , medicinal chemistry , catalysis
Abstract Lewis acid, Me 3 SiOTf, has been shown to be a promising promoter for aza‐Michael reaction of relatively acidic primary amide with α,β‐unsaturated ketone. A sries of α,β‐unsaturated ketones was transformed to their corresponding β‐amido ketones with moderate yields under this reaction condition.