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Theoretical Study of the Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by β‐Aminothiols and Thioacetates
Author(s) -
Oyaga Sandra Cotes,
Valdés José Cotuá,
Zambrano Kelly Velásquez
Publication year - 2010
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201000104
Subject(s) - methanethiol , chemistry , diethylzinc , enantioselective synthesis , catalysis , medicinal chemistry , organic chemistry , stereochemistry , sulfur
The semiempirical PM3 study of the catalytic activity of [(2S)‐1‐benzylpyrrolidinyl]methanethiol 1 , S‐([(2S)‐1‐(2,2‐dimethylpropanoyl)pyrrolidinyl]methyl)ethanethioate 2 and [(2S)‐1‐neopentylpyrrolidinyl]methanethiol 3 is described here, also an alternative mechanism for thioacetates type ligands is proposed.