Asymmetric Synthesis of a New Salen Type‐titanium Complex as the Catalyst for Asymmetric Trimethylsilylcyanation of Aldehydes | Zendy

Lin ZhengChang | Zendy; Chen Chinpiao | Zendy

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Asymmetric Synthesis of a New Salen Type‐titanium Complex as the Catalyst for Asymmetric Trimethylsilylcyanation of Aldehydes

Author(s) -

Lin ZhengChang,

Chen Chinpiao

Publication year - 2010

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.201000101

Subject(s) - chemistry , norbornane , curtius rearrangement , catalysis , ligand (biochemistry) , enantioselective synthesis , branching (polymer chemistry) , titanium , stereochemistry , organic chemistry , polymer chemistry , receptor , biochemistry

This work describes the asymmetric synthesis of a new salen‐type ligand via a Diels‐Alder reaction and Curtius rearrangement. The ligand with a norbornane skeleton was used in the trimethylsilylcyanation of aldehydes, but the enantioselectivity was 55%ee. The norborane skeleton was cleaved to destroy this rigidity, and the eanatioselectivity was thereby increased to 85%ee.

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