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One‐Pot Three‐Component Synthesis of 6‐Bromoquinolines and 6‐Iodoquinolines
Author(s) -
Wu LiQiang,
Wang Xiao,
Ma WeiWei,
Yan FuLin
Publication year - 2010
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201000086
Subject(s) - chemistry , methylene , tribromide , component (thermodynamics) , ammonium , combinatorial chemistry , organic chemistry , medicinal chemistry , thermodynamics , physics
Three‐component one‐pot synthesis of some novel 6‐bromoquinolines 5a‐5h involving the treatment of 2‐aminobenzophenone, α‐methylene carbonyl compounds, and tetrabutyl‐ammonium tribromide was achieved, and this reaction was extended to the preparation of 6‐iodoquinolines 6a‐6e by a three‐component reaction 2‐aminobenzophenone, α‐methylene carbonyl compounds, and benzyltrimethylammonium dichloroiodate in the presence of ZnCl 2 .

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