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One‐Pot, Three‐Component Condensation of Aldehydes, 2‐Naphthol and 1,3‐Dicarbonyl Compounds
Author(s) -
Mo LiPing,
Chen HongLi
Publication year - 2010
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201000025
Subject(s) - chemistry , perchloric acid , catalysis , aryl , condensation , solvent , organic chemistry , adsorption , condensation reaction , reaction conditions , heterogeneous catalysis , combinatorial chemistry , alkyl , physics , thermodynamics
A practical and efficient procedure for the one‐pot multicomponent couping of aryl aldehydes, 2‐naphthol and cyclic 1,3‐dicarbonyl compounds using perchloric acid adsorbed on silica gel (HClO 4 ‐SiO 2 ) as a highly efficient, inexpensive, convenient, reusable heterogeneous catalyst under solvent‐free conditions has been developed. Various biologically important 12‐aryl‐8,9,10,12‐tetrahydrobenzo[ a ]xanthen‐11‐one derivatives have been efficiently synthesized in high to excellent yields. The present approach offers several advantages such as shorter reaction times, simple work‐up, excellent yields, low cost, and mild reaction conditions. Furthermore, the catalyst can be recovered simply and reused without appreciable loss of its catalytic activity.