Synthesis, Characterization and Crystal Structure of Some Novel 1‐Aryl‐2‐Thioxo‐2,3‐Dihydro‐1 H ‐Quinazolin‐4‐Ones | Zendy

Saeed Aamer | Zendy; Shaheen Uzma | Zendy; Bolte Michael | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis, Characterization and Crystal Structure of Some Novel 1‐Aryl‐2‐Thioxo‐2,3‐Dihydro‐1 H ‐Quinazolin‐4‐Ones

Author(s) -

Saeed Aamer,

Shaheen Uzma,

Bolte Michael

Publication year - 2010

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.201000013

Subject(s) - chemistry , intramolecular force , nucleophilic substitution , aryl , crystal structure , nucleophilic aromatic substitution , nucleophile , single crystal , stereochemistry , medicinal chemistry , crystallography , catalysis , organic chemistry , alkyl

The base catalyzed intramolecular nucleophilic cyclization of 1‐(2‐haloaroyl)‐3‐aryl thioureas ( 1a‐i ), in the presence of DMF afforded the 1‐aryl‐2‐thioxo‐2,3‐dihydro‐1 H ‐quinazolin‐4‐ones ( 2a‐i ). The structures were confirmed by spectroscopic data, elemental analyses and in case of the 2c by single crystal X‐ray diffraction data. The mechanistic studies support an intramolecular nucleophilic substitution (S N Ar mechanism) rather than intramolecular aromatic substitution (S RN 1 mechanism).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research