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Highly Efficient CuI‐Catalyzed N ‐Arylation of Azaheterocycles with Aryl Iodides Using 1,1,1‐Tris(Hydroxymethyl)ethane as a Tridentate O ‐Donor Ligand: A Shorter Route to Toloxatone and Formal Synthesis of Linezolid
Author(s) -
Chen HsinHung,
Huang HuaMin,
Chen ShuChih,
Chen YaoJung
Publication year - 2010
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.201000002
Subject(s) - chemistry , hydroxymethyl , tris , aryl , catalysis , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , organic chemistry , receptor , biochemistry , alkyl
An efficient copper‐catalyzed N ‐arylation of azaheterocycles with aryl iodides using 1,1,1‐tris(hydroxymethyl)ethane as a tridentates O ‐donor ligand has been accomplished in good to excellent yields. Moreover, this highly efficient catalyst system has been successfully demonstrated to one‐step synthesis of toloxatone and a shorter route to formal synthesis of linezolid in good yields.