Highly Efficient CuI‐Catalyzed  N ‐Arylation of Azaheterocycles with Aryl Iodides Using 1,1,1‐Tris(Hydroxymethyl)ethane as a Tridentate  O ‐Donor Ligand: A Shorter Route to Toloxatone and Formal Synthesis of Linezolid | Zendy

Chen HsinHung | Zendy; Huang HuaMin | Zendy; Chen ShuChih | Zendy; Chen YaoJung | Zendy

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Highly Efficient CuI‐Catalyzed N ‐Arylation of Azaheterocycles with Aryl Iodides Using 1,1,1‐Tris(Hydroxymethyl)ethane as a Tridentate O ‐Donor Ligand: A Shorter Route to Toloxatone and Formal Synthesis of Linezolid

Author(s) -

Chen HsinHung,

Huang HuaMin,

Chen ShuChih,

Chen YaoJung

Publication year - 2010

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.201000002

Subject(s) - chemistry , hydroxymethyl , tris , aryl , catalysis , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , organic chemistry , receptor , biochemistry , alkyl

An efficient copper‐catalyzed N ‐arylation of azaheterocycles with aryl iodides using 1,1,1‐tris(hydroxymethyl)ethane as a tridentates O ‐donor ligand has been accomplished in good to excellent yields. Moreover, this highly efficient catalyst system has been successfully demonstrated to one‐step synthesis of toloxatone and a shorter route to formal synthesis of linezolid in good yields.

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