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Synthesis and Characterization of Novel Arylaldehyde (Arylketone)‐(4‐Substituted phenyl‐5‐Substituted phenoxy‐Methyl‐4 H ‐1,2,4‐Triazole‐3‐yl)‐Thiol Acetyl Hydrazones
Author(s) -
Zhang HengWen,
Li YanPing,
Liu ChenJiang,
Li HaiLong,
Sun WenLi
Publication year - 2009
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200900172
Subject(s) - chemistry , hydrazone , 1,2,4 triazole , hydrazide , crystal structure , thiol , medicinal chemistry , proton nmr , single crystal , triazole , stereochemistry , organic chemistry , crystallography
Fourteen novel arylaldehyde (arylketone)‐(4‐substituted phenyl‐5‐substituted phenoxy‐methyl‐4 H ‐1,2,4‐triazole‐3‐yl)‐thiol acetyl hydrazone derivatives ( 5a‐5g, 6a‐6g ) were synthesized by 4‐substituted phenyl‐5‐substituted phenoxy‐methyl‐1,2,4‐triazole‐3‐thione as starting material according to substructure link principle, followed by thioetherification, hydrazide hydrazone reaction. The structures of these compounds were confirmed by IR, 1 H NMR and elemental analysis. Crystal structure of compounds 1b and 6d were determined by the X‐ray diffraction.