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Facile Access to Benzothiazole‐Containing Pyrrolo[1,2‐ a ]quinolines and Pyrrolo[2,1‐ a ]isoquinolines via Nitrogen Ylides
Author(s) -
Dawood Kamal M.,
Ragab Eman A.,
Khedr Nabila A.
Publication year - 2009
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200900170
Subject(s) - benzothiazole , isoquinoline , chemistry , quinoline , acetylene , benzene , medicinal chemistry , cycloaddition , ethylene , nitrogen , organic chemistry , catalysis
Quinoline and isoquinoline react with 2‐(bromoacetyl)benzothiazole ( 1 ) in dry benzene to give the corresponding quinolinium and isoquinolinium salts 2 and 10 which undergo base‐mediated [3+2] 1,3‐dipolar cycloaddition with some acetylene and ethylene derivatives to give the corresponding benzothiazole‐containing pyrrolo[1,2‐ a ]quinoline and pyrrolo[2,1‐ a ]isoquinoline derivatives.