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A Simple and Efficient Procedure for Synthesis of Optically Active 1,2,4‐Triazolo‐[3,4‐ b ]‐1,3,4‐Thiadiazole Derivatives Containing l ‐Amino Acid Moieties
Author(s) -
Foroughifar Naser,
Mobinikhaledi Akbar,
Ebrahimi Sattar,
Fard Mohammad Ali Bodaghi,
Moghanian Hassan
Publication year - 2009
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200900151
Subject(s) - chemistry , optically active , amino acid , thiadiazoles , proton nmr , elemental analysis , stereochemistry , organic chemistry , combinatorial chemistry , biochemistry
Some new and optically active 1,2,4‐triazolo thiadiazoles bearing N ‐phthaloyl‐ l ‐amino acids were synthesized by reaction of 4‐amino‐5‐(3‐ or 4‐)pyridyl‐3‐mercapto‐(4 H )‐1,2,4‐triazoles with N ‐phthaloyl‐ l ‐amino acids in the presence of phosphorus oxychloride. All the newly synthesized compounds were confirmed by IR, 1 H NMR, 13 C NMR and elemental analysis.