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Synthesis and Characterization of Novel Stilbene Derivatives with 1,3,4‐Oxadiazole Unit
Author(s) -
He DaoHang,
Zhu YongChuang,
Yang ZhuoRu,
Hu AiXi
Publication year - 2009
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200900039
Subject(s) - chemistry , oxadiazole , hydrazine (antidepressant) , phosphonate , hydrate , halogenation , wittig reaction , organic chemistry , combinatorial chemistry , chromatography
Four novel stilbene derivatives containing 1,3,4‐oxadiazole unit have been synthesized in four steps with overall yields (27∼35%). The synthetic route involved one‐step installation of 2,5‐di‐ p ‐tolyl‐1,3,4‐oxadiazol via the direct coupling of p ‐toluic acid with hydrazine hydrate promoted by PPA , benzylic bromination, conventional phosphonate formation, and Wittig‐Horner olefination.