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Synthesis and Antiproliferative Activity of 6‐Ferrocenyl‐3‐Substituted 7 H ‐1,2,4‐Triazolo[3, 4‐ b ]‐1,3,4‐Thiadiazines
Author(s) -
Han Yin,
Wang Qin,
Du YuPing,
Lv MingHua,
Hui XinPing
Publication year - 2009
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200900031
Subject(s) - chemistry , fibroblast , fibrosarcoma , cell culture , stereochemistry , viability assay , cell , biochemistry , in vitro , genetics , biology
Five new 6‐ferrocenyl‐3‐substituted 7 H ‐1,2,4‐triazolo[3, 4‐ b ]‐1,3,4‐thiadiazines ( 3a‐e ) have been synthesized and characterized on the basis of elemental analyses and spectral data. The antiproliferative activities were examined in two human cell lines (BJ and HT 1080) with the acid phosphatase assay. The results showed that all compounds could reduce cell viability. The significant difference between the two cell lines was that fibrosarcoma HT 1080 cells could indeed be more susceptible to the compounds than the normal fibroblast BJ cells.