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Chemiluminescence Determination of Sulpiride in Pharmaceutical Preparations and Biological Fluids Based on KMnO 4 ‐Tween 80 Reaction
Author(s) -
Li YinHuan
Publication year - 2009
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200900023
Subject(s) - sulpiride , chemistry , chemiluminescence , detection limit , chromatography , relative standard deviation , analytical chemistry (journal) , biochemistry , receptor , antagonist
Chemiluminescence (CL) of an acidic KMnO 4 system in the presence of Tween 80 was investigated for the determination of sulpiride. Strong CL was recorded when a mixture of sulpiride and Tween 80 was injected into acidic KMnO 4 solution. The experimental parameters affecting the CL intensity were carefully studied using flow injection mode. Under the optimum conditions, the CL intensity was proportional to the concentration of sulpiride in the range of 5.0 × 10 −7 ∼ 1.0 × 10 −4 g mL −1 . The detection limit is 1.6 × 10 −7 g mL −1 sulpiride, and the relative standard deviation for 1.0 × 10 −6 g mL −1 sulpiride solution is 1.5% (n = 11). The proposed method has been successfully applied to the determination of sulpiride in tablets and in spiked human plasma and urine samples.