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Simultaneous Spectrophotometric Determination of Paracetamol and P‐Aminophenol by Using Mean Centering of Ratio Kinetic Profiles
Author(s) -
Kamyabi Mohammad Ali
Publication year - 2009
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200900020
Subject(s) - chemistry , reagent , relative standard deviation , detection limit , prussian blue , chromatography , standard deviation , kinetic energy , analytical chemistry (journal) , spectrophotometry , absolute deviation , statistics , electrochemistry , mathematics , electrode , organic chemistry , physics , quantum mechanics
A specific spectrophotometric method was developed for simultaneous determination of paracetamol (PCT) and p‐aminophenol (PAP) in water samples without prior separation steps. The method is based on the mean centering of ratio kinetic profiles. Paracetamol and P‐aminophenol react with Fe(III)/hexacyanoferrate(III) complex and result in the formation of colored complex, i.e. Prussian Blue. The differences in the rate of reaction of PCT and PAP with reagents make their simultaneous determination feasible by using mean centering of ratio kinetic profiles. The experimental parameters, such as reagent concentrations and pH were optimized for getting results with minimum errors. The analytical characteristics of the method such as detection limit, accuracy, precision, relative standard deviation (R.S.D.) and relative standard error (R.S.E.) for the simultaneous determination of binary mixtures of p‐aminophenol and acetaminophen were calculated. The results show that the method was capable of simultaneous determination of 0.5–21.0 μg mL −1 and 0.1–15.0 μg mL −1 of PCT and PAP, respectively. The proposed method was successfully applied to the simultaneous determination of paracetamol and p‐aminophenol in several pharmaceutical products and synthetics mixtures.