Synthesis and Biological Activity Evaluation of Novel Imidazolidinedione Derivatives, as Potent Antidiabetic Agent | Zendy

Wang RunLing | Zendy; Li WenMing | Zendy; Liu MengYuan | Zendy; Xu WeiRen | Zendy

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Synthesis and Biological Activity Evaluation of Novel Imidazolidinedione Derivatives, as Potent Antidiabetic Agent

Author(s) -

Wang RunLing,

Li WenMing,

Liu MengYuan,

Xu WeiRen

Publication year - 2009

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200900005

Subject(s) - chemistry , alloxan , combinatorial chemistry , biological activity , pharmacology , traditional medicine , diabetes mellitus , computational biology , biochemistry , in vitro , endocrinology , medicine , biology

A set of novel imidazolidinedione derivatives were synthesized and evaluated as potential antidiabetic agents. Imidazolidinedione scaffold‐based molecules were synthesized and validated on a mice hyperglycemia model caused by alloxan. As a result, three of them showed antihyperglycemic activities. This research provides useful clues for further design and discovery of antidiabetic agents.

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