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Synthesis and Biological Activity Evaluation of Novel Imidazolidinedione Derivatives, as Potent Antidiabetic Agent
Author(s) -
Wang RunLing,
Li WenMing,
Liu MengYuan,
Xu WeiRen
Publication year - 2009
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200900005
Subject(s) - chemistry , alloxan , combinatorial chemistry , biological activity , pharmacology , traditional medicine , diabetes mellitus , computational biology , biochemistry , in vitro , endocrinology , medicine , biology
A set of novel imidazolidinedione derivatives were synthesized and evaluated as potential antidiabetic agents. Imidazolidinedione scaffold‐based molecules were synthesized and validated on a mice hyperglycemia model caused by alloxan. As a result, three of them showed antihyperglycemic activities. This research provides useful clues for further design and discovery of antidiabetic agents.