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Synthesis and In Vivo Anticonvulsant Screening of Coumarin Incorporated Schiff Bases of 1,3,4‐Oxadiazoles
Author(s) -
Siddiqui Nadeem,
Bhat Mashooq A.,
Khan Suroor A.,
Ahsan Waquar,
Alam M. Shamsher
Publication year - 2008
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200800199
Subject(s) - chemistry , coumarin , anticonvulsant , phenytoin , in vivo , neurotoxicity , pharmacology , drug , schiff base , combinatorial chemistry , stereochemistry , organic chemistry , toxicity , epilepsy , medicine , microbiology and biotechnology , neuroscience , biology
A series of coumarin incorporated Schiff bases of 1,3,4‐oxadiazoles ( 1‐18 ) was synthesized. The structures of the synthesized compounds were confirmed on the basis of spectral data and elemental analysis. The anticonvulsant and neurotoxicity was studied by maximal electroshock seizure (MES) and rotorod method, respectively. A majority of the compounds were active in MES test. All the compounds were less neurotoxic than the standard drug phenytoin.