Premium
Synthesis of 3‐Aryl‐2,5‐Dihydro‐1‐Benzoxepines from Phenol via Ring‐Closing Metathesis
Author(s) -
Tsai JuiChi,
Li SieRong,
Chen LiangYeu,
Chen PoYuan,
Joung JiaYing,
Shu ChungJung,
Lo YuFuan,
Lin ChunNan,
Wang EngChi
Publication year - 2008
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200800197
Subject(s) - chemistry , phenol , ring closing metathesis , aryl , wittig reaction , metathesis , claisen rearrangement , salt metathesis reaction , ring (chemistry) , alkylation , organic chemistry , combinatorial chemistry , stereochemistry , catalysis , alkyl , polymerization , polymer
Abstract In this paper, the synthesis of 3‐aryl‐2,5‐dihydro‐1‐benzoxepines is described. While the reaction was started from phenol and based on the sequential reactions such as Claisen rearrangement, O ‐alkylation, Wittig reaction, and ring‐closing metathesis (RCM), a series of new 3‐aryl‐1‐benzoxepines were prepared in good overall yields.