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Synthesis and Structural Characterisation of Derivatives of Tricyclo[5.2.1.0 2,6 ]Dec‐8‐Ene‐3,5‐Dione with an Expected Antimicrobial Activity
Author(s) -
Struga Marta,
Krawiecka Mariola,
Kossakowski Jerzy,
Stefańska Joanna,
Miroslaw Barbara,
Koziol Anna E.
Publication year - 2008
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200800187
Subject(s) - chemistry , antimicrobial , bicyclic molecule , ene reaction , dicarboxylic acid , gram , stereochemistry , bacteria , organic chemistry , biology , genetics
Anhydrides, imides, N ‐ethylimides, N ‐hydroxyimides and N ‐aminoimides of 1,4,5,6‐tetramethyl‐bicyclo[5.2.1.0 2,6 ]hept‐5‐ene‐2,3‐dicarboxylic acid, 1,4,5,6,7‐pentamethyl‐bicyclo[5.2.1.0 2,6 ]hept‐5‐ene‐2,3‐dicarboxylic acid and 7‐ethyl‐1,4,5,6‐tetramethyl‐bicyclo[5.2.1.0 2,6 ]hept‐5‐ene‐2,3‐dicarboxylic acid were obtained. Antimicrobial activity of the newly obtained derivatives was tested against selected Gram‐positive and Gram‐negative bacteria and fungi of the Candida species. The structures of obtained compounds and their antimicrobial activity were compared. Structure of 1b, 2b and 1e were determined by an X‐ray analysis.