Facile Synthesis of 3(2 H )‐Pyridazinones and 2(3 H )‐Furanones of Anticipated Biological Activities | Zendy

Morsy J. M. | Zendy

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Facile Synthesis of 3(2 H )‐Pyridazinones and 2(3 H )‐Furanones of Anticipated Biological Activities

Author(s) -

Morsy J. M.

Publication year - 2008

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200800185

Subject(s) - chemistry , hydrazine (antidepressant) , hydrate , acetic anhydride , acetic acid , distilled water , medicinal chemistry , organic chemistry , biochemistry , chromatography , catalysis

3‐Aroyl‐2‐arylpropionic acids 2a‐e were utilized to synthesize 3(2 H )‐pyridazinones 3a‐e and 2(3 H )‐furanones 6 through reaction with hydrazine hydrate and freshly distilled acetic anhydride, respectively, in the hope of obtaining new 3(2 H )‐pyridazinones with no ulcerogenic side effect or with negligible general side effects as those currently used NSAID S as well as biologically active 2(3 H )‐furanones.

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