Effect of Indole‐3‐Acetic Acid Analogs on the Differentiation of HL‐60 Cells | Zendy

Lien JinCherng | Zendy; Jiang YuDong | Zendy; Chen ChunJen | Zendy; Kuo ShengChu | Zendy; Huang LiJiau | Zendy

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Effect of Indole‐3‐Acetic Acid Analogs on the Differentiation of HL‐60 Cells

Author(s) -

Lien JinCherng,

Jiang YuDong,

Chen ChunJen,

Kuo ShengChu,

Huang LiJiau

Publication year - 2008

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200800171

Subject(s) - chemistry , acetamide , retinoic acid , acetic acid , indole test , carboxamide , carboxylic acid , stereochemistry , biochemistry , organic chemistry , gene

In continuing search for novel cell differentiation agents, a series of derivatives of indole‐3‐acetic acid and indole‐3‐carboxylic acid were prepared and tested against HL‐60 cells for their differentiation and antiproliferation activities. Among them, N ‐ethyl‐1‐benzylindole‐3‐carboxamide ( 14 ) was the most potent, whereas N ‐methyl 1‐benzylindole‐3‐acetamide ( 5 ) and N ‐methyl 1‐benzylindole‐3‐carboxamide ( 13 ) synergistically potentiated with all‐ trans ‐retinoic acid to induce cell differentiation as well as antiproliferation. Our results indicate that these compounds are effective cell differentiation and antiproliferation agents in combination with retinoic acid.

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