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Bioactive Components from the Mycelium of Antrodia Salmonea
Author(s) -
Shen ChienChang,
Lin ChwanFwu,
Huang YuLing,
Wan ShrTing,
Chen ChinChu,
Sheu SenJe,
Lin YiChin,
Chen ChienChih
Publication year - 2008
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200800127
Subject(s) - chemistry , mycelium , benzoquinone , cytotoxicity , stereochemistry , organic chemistry , in vitro , biochemistry , botany , biology
Three new compounds, 2,4‐dimethoxy‐6‐methylbenzene‐1,3‐diol ( 1 ), salmoquinone ( 2 ), and 3‐(4‐hydroxyphenyl)‐4‐isobutyl‐1 H ‐pyrrole‐2,5‐dione ( 3 ), together with six known compounds, 2‐methoxy‐6‐methyl‐ p ‐benzoquinone ( 4 ), 2,3‐dimethoxy‐5‐methyl‐ p ‐benzoquinone ( 5 ), 2‐hydroxy‐5‐methoxy‐3‐methyl‐ p ‐benzoquinone ( 6 ), eburcoic acid ( 7 ), fomefficinic acid C ( 8 ), and a pyrroledione ( 9 ), were isolated from the mycelium of Antrodia salmonea. The structures of these compounds were elucidated by spectrometric analyses including IR, NMR, and MS. Among these compounds, 4 and 5 exhibited cytotoxicity against KB, HepG2, and H2058 cell lines.
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