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Synthesis of Deuterium Labeled Standards of 1‐Benzylpiperazine, Fenetylline, Nicocodeine and Nicomorphine
Author(s) -
You ZongYi,
Chen YiJing,
Wang YuYun,
Chen Chinpiao
Publication year - 2008
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200800099
Subject(s) - chemistry , designer drug , piperazine , gas chromatography , identification (biology) , mass spectrometry , chromatography , gas chromatography–mass spectrometry , organic chemistry , pharmacology , drug , medicine , botany , biology
Abstract Increasingly abused, 1‐benzylpiperazine (BZP), fenetylline, nicocodeine and nicomorphine are central nervous system stimulants with neurotoxic properties. In recent years, many controlled substance analogs (designer drugs) with a large variety of structures have reached illegal markets, making their identification difficult. This work studies the synthesis of BZP‐ d 7 , fenetylline‐ d 4 , nicocodeine‐ d 4 and nicomorphine‐ d 8 , as internal standards for use in gas chromatography‐mass spectrometry (GC‐MS) analysis for identification of these controlled substances.