Premium
Novel and Efficient Procedure for the Regiocontrolled Preparation of α‐(Phenylsulfanyl) Carbonyl Compounds
Author(s) -
Lee FaYen,
Zhu JiaLiang
Publication year - 2008
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200800097
Subject(s) - chemistry , regioselectivity , lithium (medication) , organic chemistry , combinatorial chemistry , catalysis , medicine , endocrinology
A new procedure for the regiocontrolled synthesis of α‐(phenylsulfanyl) carbonyl compounds has been developed, making use of lithium naphthalenide induced reductive sulfenylation of α‐cyano carbonyl compounds as a key operation. Through this protocol, a variety of á‐(phenylsulfanyl) carbonyl compounds has been prepared in moderate to high yields. The completely regioselective sulfenylation was observed in most of the cases.